ImportantIt is possible that the main title of the report Angioimmunoblastic T-Cell Lymphoma is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
Angioimmunoblastic T-cell lymphoma (AITL) is a rare form of non-Hodgkin lymphoma, which is a group of related malignancies (cancers) that affect the lymphatic system (lymphomas). The lymphatic system functions as part of the immune system and helps to protect the body against infection and disease. It consists of a network of tubular channels (lymph vessels) that drain a thin watery fluid known as lymph from different areas of the body into the bloodstream. Lymph accumulates in the tiny spaces between tissue cells and contains proteins, fats, and certain white blood cells known as lymphocytes. As lymph moves through the lymphatic system, it is filtered by a network of small structures known as lymph nodes that help to remove microorganisms (e.g., viruses, bacteria, etc.) and other foreign bodies. Groups of lymph nodes are located throughout the body, including in the neck, under the arms (axillae), at the elbows, and in the chest, abdomen, and groin. Lymphocytes are stored within lymph nodes and may also be found in other lymphatic tissues. In addition to the lymph nodes, the lymphatic system includes the spleen, which filters worn-out red blood cells and produces lymphocytes, and bone marrow, which is the spongy tissue inside the cavities of bones that manufactures blood cells. Lymphatic tissue or circulating lymphocytes may also be located in other regions of the body. There are two main types of lymphocytes: B-lymphocytes (B-cells), which may produce specific antibodies to "neutralize" certain invading microorganisms, and T-lymphocytes (T-cells), which may directly destroy microorganisms or assist in the activities of other lymphocytes. AITL results from errors in the production of a T-cell or transformation of a T-cell into a malignant cell. Abnormal, uncontrolled growth and multiplication (proliferation) of malignant T-cells may lead to enlargement of a specific lymph node region or regions; involvement of other lymphatic tissues, such as the spleen and bone marrow; and spread to other bodily tissues and organs. A key and differentiating aspect of AITL is dysfunction of the immune system, which can lead to a variety of symptoms. Individuals with AITL may develop a rash, persistent fever, unintended weight loss, tissue swelling due to the accumulation of fluid (edema) and additional symptoms. The exact, underlying cause of AITL is not fully understood.
Leukemia & Lymphoma Society 1311 Mamaroneck Avenue Suite 310 New York, NY 10605 Tel: (914)949-5213 Fax: (914)949-6691 Tel: (800)955-4572 Email: infocenter@LLS.org Internet: http://www.LLS.orgAmerican Cancer Society, Inc. 1599 Clifton Road NE Atlanta, GA 30329 USA Tel: (404)320-3333 Tel: (800)227-2345 TDD: (866)228-4327 Internet: http://www.cancer.orgNational Cancer Institute Physician Data Query Office of Communications and Education Public Inquiries Office 6116 Executive Blvd Suite 300 Bethesda, MD 20892-8322 Tel: (800)422-6237 Email: email@example.com Internet: http://www.cancer.gov/cancertopics/pdq/cancerdatabaseNIH/National Institute of Allergy and Infectious Diseases Office of Communications and Government Relations 6610 Rockledge Drive, MSC 6612 Bethesda, MD 20892-6612 Tel: (301)496-5717 Fax: (301)402-3573 Tel: (866)284-4107 TDD: (800)877-8339 Email: firstname.lastname@example.org Internet: http://www.niaid.nih.gov/National Cancer Institute 6116 Executive Blvd MSC 8322 Room 3036A Bethesda, MD 20892-8322 USA Tel: (301)435-3848 Tel: (800)422-6237 TDD: (800)332-8615 Email: email@example.com Internet: http://www.cancer.govCancer Hope Network 2 North Road Suite A Chester, NJ 07930 Tel: (908)879-4039 Fax: (908)879-6518 Tel: (800)552-4366 Email: firstname.lastname@example.org Internet: http://www.cancerhopenetwork.orgOncoLink: The University of Pennsylvania Cancer Center Resource 3400 Spruce Street 2 Donner Philadelphia, PA 19104-4283 USA Tel: (215)349-8895 Fax: (215)349-5445 Email: email@example.com Internet: http://www.oncolink.upenn.eduLymphoma Research Foundation 115 Broadway Suite 1301 New York, NY 10006 USA Tel: (212)349-2910 Fax: (212)349-2886 Tel: (800)235-6848 Email: LRF@lymphoma.org Internet: http://www.lymphoma.orgLymphoma Foundation Canada 16-1375 Southdown Road Suite 236 Mississauga Ontario, L5J 2Z1 Canada Tel: (905) 822-5135 Fax: (905) 814-9152 Tel: (866) 659-5556 Email: firstname.lastname@example.org Internet: http://www.lymphoma.caLymphoma Association (UK) PO Box 386 Aylesbury Bucks, Intl HP20 2GA United Kingdom Tel: 01296 619400 Email: lymphoma.org.uk Internet: http://www.lymphoma.org.ukInternational Cancer Alliance for Research and Education (ICARE) 4853 Cordell Avenue Suite 14 Bethesda, MD 20814 Tel: (301)656-3461 Fax: (301)654-8684 Tel: (800)422-7361 Email: email@example.com Internet: http://www.icare.orgCancer Care, Inc. 275 Seventh Avenue New York, NY 10001 Tel: (212)712-8400 Fax: (212)719-0263 Tel: (800)813-4673 Email: firstname.lastname@example.org Internet: http://www.cancercare.orgRare Cancer Alliance 1649 North Pacana Way Green Valley, AZ 85614 USA Tel: (520)625-5495 Fax: (615)526-4921 Internet: http://www.rare-cancer.orgFriends of Cancer Research 1800 M Street NW Suite 1050 South Washington, DC 22202 Tel: (202)944-6700 Email: email@example.com Internet: http://www.focr.org
This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".
The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this reportThis disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email firstname.lastname@example.orgLast Updated: 2/16/2011Copyright 1988, 1989, 2000, 2011 National Organization for Rare Disorders, Inc.
The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.
It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report
This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.
For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email email@example.com
Last Updated: 2/16/2011Copyright 1988, 1989, 2000, 2011 National Organization for Rare Disorders, Inc.
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