Our epidemiologists lead population-based studies that identify the causes and risk factors of cardiovascular disease.
Dr. Horne has been with Intermountain since 1996 and also holds an adjunct appointment as an assistant professor in Genetic Epidemiology in the Department of Medicine at the University of Utah.
Dr. Horne’s recent genetics publications include the first report that chromosome 9p21 variants are not associated with myocardial infarction (only with coronary artery disease), a novel finding that stirred debate in the scientific community. Also, an international consortium led by Dr. Horne published new pharmacogenetic warfarin dose refinement algorithms in 2012.
His most academically noteworthy paper to date was a genome-wide association study for peripartum cardiomyopathy, a rare but devastating outcome that afflicts about 1 in 3,000 pregnant women, in which a genetic marker on chromosome 12 was identified as a predictor of the disease.
For the first 11 years of her career, Dr. Knight worked as a master level statistician studying injury and emergency medical care. In 2010, Dr. Knight obtained a PhD in Biomedical Informatics with a focus on genetic epidemiology. For her doctorate dissertation, she was awarded the James W. Prahl Memorial Award for Outstanding Contributions by a Graduate Student in Biological or Biomedical Sciences at the University of Utah. Upon completing her dissertation, Dr. Knight took a postdoctoral research associate position in the Division of Genetic Epidemiology in the Department of Internal Medicine at the University of Utah.
After her postdoctoral training, Dr. Knight joined Intermountain Heart Institute as a Cardiovascular and Genetic Epidemiologist. Since joining the Intermountain team, Dr. Knight has overseen the Intermountain Genealogy Registry for use in family-based genetic research. She has also been involved in the study of relationship between respiratory viral infections and cardiovascular ischemic events.
Dr. May’s recent publications involve the evaluation of vitamin D and its role in cardiovascular disease and incident depression. It has long been known that adequate vitamin D is needed for bone health and muscle functioning. However, we are now discovering that vitamin D is important in other disease processes, such as cardiovascular disease and its associated risk factors.
Dr. May has also published papers on the role depression plays in cardiovascular disease. She reported that among patients with coronary disease, those with depression have a higher risk of developing heart failure than those without depression. In another study, she found that depression is associated with lower adherence to lipid lowering medications. These medications are important in patients with coronary disease because they have been shown to help prevent further heart problems when taken regularly.