David Crockett, PhD, is the Director of Bioinformatics at Intermountain Healthcare. Dr. Crockett works to push clinical genetics more broadly into patient care. He has been involved in research design, clinical studies and data strategies integral to multi-disciplinary teams for more than 20 years. He is a Data Scientist that’s passionate for genomic medicine, predictive analytics and real world applications of informatics.
Areas of Focus
- Clinical Genetics
- Gene Variant Archives
- Molecular Oncology
- Next-Gen Sequencing
- Precision Medicine
Significance to Patient Care
The future of precision medicine will, in large part, be determined by understanding genetic variation in each patient. Precision medicine simply means that patients are quickly and appropriately placed into the path of care that is most effective and cost efficient for them at that time. Precision medicine also integrates research with clinical practice. This cumulative knowledge empowers clinicians to create individualized care for each patient.
Andrews J, Crockett DK, Curd S. Precision medicine growth hinges on electronic health records. Healthcare IT News. Jan 2016.
Crockett DK, Voelkerding KV. Bioinformatics Tools in Clinical Genomics, invited chapter for Genomic Applications in Pathology. Editors, George Netta and Iris Schrijver. Springer Publication Date: July 31, 2014. ISBN-10: 1493907263.
O’Fallon BD, Wooderchak-Donahue W, Bayrak-Toydemir P, Crockett DK. VarRanker: Rapid Prioritization of Sequence Variations Associated with Human Disease. BMC Bioinformatics. 2013;14 Suppl 13:S1. Epub 2013 Oct 1.
Savige J, Ars E, Cotton RG, Crockett D, Dagher H, Deltas C, Ding J, Flinter F, Pont-Kingdon G, Smaoui N, Torra R, Storey H. DNA variant databases improve test accuracy and phenotype prediction in Alport syndrome. Pediatr Nephrol. 2013 May 30.
O’Fallon BD, Wooderchak-Donahue W, Crockett DK. A support vector machine for identification of single-nucleotide polymorphisms from next-generation sequencing data. Bioinformatics. 2013 Jun 1;29(11):1361-6.
Crockett DK, Bioinformatics for the Clinical Lab Manager. ADVANCE, March 4, 2013 - Vol 22, Number 3.
Procter M, Wolf B, Crockett DK, Mao R. The Biotinidase Gene Variants Registry: A Paradigm Public Database. Genes, Genomics, Genetics (G3). 2013 Mar 11;g3.113.005835; doi:10.1534/g3.113.005835.
Kushnir MM, Naessén T, Rockwood AL, Crockett DK, Bergquist J. Protein and Steroid Profiles in Follicular Fluid after Ovarian Hyperstimulation as Potential Biomarkers of IVF Outcome. J Proteome Res. 2012 Oct 5;11(10):5090-100.
Crockett DK, Ridge PG, Wilson AR, Lyon E, Williams MS, Narus, SP, Facelli JC, Mitchell JA. Consensus: A framework for evaluation of uncertain gene variants in laboratory test reporting. Genome Med. 2012 May 28;4(5):48.
Crockett DK, Lyon E, Williams MS, Narus SP, Facelli JC, Mitchell JA. Utility of gene-specific algorithms for predicting pathogenicity of uncertain gene variants. J Am Med Inform Assoc 2012;19:207-211.
Escobar H, Reyes-Vargas E, Jensen PE, Delgado JC, Crockett DK. Utility of characteristic QTOF MS/MS fragmentation for MHC class I peptides. J Proteome Res. 2011 May 6;10(5):2494-507.
Crockett DK, Piccolo SR, Ridge PG, Margraf RL, Lyon E, Williams MS, Mitchell JA. Predicting phenotypic severity of uncertain gene variants in the RET proto-oncogene. PLoS One. 2011 Mar 30;6(3):e18380.
Crockett DK, Pont-Kingdon G, Gedge F, Sumner K, Seamons R, Lyon E. The Alport syndrome COL4A5 variant database. Hum Mutat. 2010 Aug;31(8):E1652-7.
Crockett DK, Kushnir MM, Phillips JD, Rockwood AL. Time-of-flight analysis of the ferroportin-hepcidin binding domain complex for accurate mass confirmation of bioactive hepcidin 25. Clinica Chimica Acta. 2010 Vol. 411 (5-6): 453-5.