The Intermountain Biorepository is currently assisting in a number of key research projects and has contributed to discoveries published in various medical journals. Please see a selection of these research contributions below.

Published Research

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"Reparameterization of PAM50 Expression Identifies Novel Breast Tumor Dimensions and Leads to Discovery of a Genome-Wide Significant Breast Cancer Locus at 12q15"


Objective

To suggest a new approach to describe tumor expression diversity, provide new avenues for germline studies, and propose a new breast cancer locus.

Journal

Cancer Epidemiology, Biomarkers & Prevention/April 12, 2018 (Epub ahead of print)

Authors

Michael J. Madsen, Stacey Knight, Carol Sweeney, Rachel E. Factor, Mohamed E. Salama, Inge J. Stijleman, Venkatesh Rajamanickam, Bryan Welm, Sasi Arunachalam, Brandt Jones, Rakesh Rachamadugu, Kerry Rowe, Melissa Cessna, Alun Thomas, Lawrence H. Kushi, Bette Caan, Philip S. Bernard, and Nicola J. Camp

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genomics-research

"Significant Linkage Evidence for Interstitial Cystitis/Painful Bladder Syndrome on Chromosome 3"


Objective

To determine a genetic etiology of related interstitial cystitis/painful bladder syndrome cases.

Journal

The Journal of Urology/2018-01-01 Volume 199, Issue 1, Pages 172-177

Authors

Kristina Allen-Brady, Kerry Rowe, Melissa Cessna, Sara Lenherr, and Peggy Norton

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Intermountain Biorepository 4

"Genomic Analysis of Adult B-ALL Identifies Potential Markers of Shorter Survival"


Objective

To add to the understanding of B-ALL that upon further validation may help identify patients who would benefit from upfront treatment intensification.

Journal

Leukemia Research, 2017-05-01, Volume 56, Pages 44-51

Authors

Shiven Patel, Clinton C. Mason, Martha J. Glenn, Christian N. Paxton, Sara T. South, Melissa H. Cessna, Julie Asch, Erin F. Cobain, Dale L. Bixby, Lauren B. Smith, Shalini Reshmi, Julie M. Gastier-Foster, Joshua D. Schiffman, and Rodney R. Miles

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Intermountain Biorepository 2

"Tissue Microarray Advanced Techniques for Sampling Donor Blocks With Limited Tissues – Introduction to ‘The Radical-TMA’"


Objective

To develop a radical-tissue microarray technique that requires only minute tissue samples from donor blocks with limited tissues.

Journal

Journal of Histotechnology, Volume 37, 2014 – Issue 1

Authors

Thom Jensen, Melissa Cessna, Dylan Miller, and Janet Hansen

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Intermountain Biorepository 3

"Biobanking Informatics Infrastructure to Support Clinical and Translational Research"


Objective

To facilitate next generation research by leveraging the combined resources of the University of Utah Health Sciences and Intermountain Healthcare institutions through an infrastructure which links biospecimens and electronic health records.

Journal

AMIA Summits Transl Sci Proc. 2013; 2013:132-5

Authors

Bernie LaSalle, Michael Varner, Jeff Botkin, Marc Jackson, Louisa Stark, Melissa Cessna, Carolyn Orthner, Nathan Hulse, Aldo Bernasconi, Randy Madsen, Dustin Schultz, Richard Bradshaw, and Joyce Mitchell

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"Longitudinal Evaluation of Microvessel Density in Survivors vs. Nonsurvivors of Cardiac Pathologic Antibody-Mediated Rejection"


Objective

To better understand the connection between antibody-mediated rejection of cardia allografts and microvascular injury.

Journal

Cardiovascular Pathology, 2012-11-01, Volume 21, Issue 6, Pages 445-454

Authors

Monica P. Revelo, Dylan V. Miller, Josef Stehlik, Kim Brunisholz, Stavros Drakos, Edward M. Gilbert, Melanie Everitt, Deborah Budge, Rami Alharethi, Gregory Snow, Elizabeth H. Hammond, and Abdallah G. Kfoury

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