If you’ve ever tried to lose weight, you know how frustrating it can be. You eat healthy, exercise, and still don’t see the results you want. That’s because losing weight – and keeping it off – is about more than just willpower.

For many people, traditional weight loss methods don’t address the biological factors that contribute to weight gain. That’s where GLP-1 medications like Wegovy® (semaglutide) and Zepbound® (tirzepatide) come in.

“These medications don’t just help people lose weight. They also improve overall health,” says Patrick Welch, PharmD, BCACP, an Advanced Clinical Pharmacist at Intermountain. “Many patients see lower blood pressure, better cholesterol levels, and even a reduced risk of type 2 diabetes.”

But there’s more to GLP-1 medications than you might think. To get the best results, it’s important to understand how they work, who they’re for, and how to use them effectively.

1. How do GLP-1s work?

GLP-1 (glucagon-like peptide-1) medications were originally developed to treat type 2 diabetes, but researchers soon discovered that one of their side effects – reducing hunger – made them highly effective for weight loss.

GLP-1s work with your body’s natural systems to help you lose weight by:

• Regulating appetite – You feel full longer, so you eat less without feeling deprived.
• Slowing digestion – It helps control your blood sugar levels and reduces cravings.
• Improving insulin function – It makes it easier for your body to burn fat efficiently.

GLP-1 medications are typically taken as a once-weekly injection. You use a small needle to inject the medication into fatty tissue – usually in your belly, thighs, arms, or upper buttocks. Most people find that with a little practice, it becomes a simple part of their routine.

2. Who is a good fit for GLP-1 medications?

According to the FDA, GLP-1s are approved for people with obesity (BMI of 30 or higher).

But here’s something many don’t realize: If your BMI is 27 or higher and you have health conditions like high blood pressure, high cholesterol, or diabetes, you might also qualify.

Your doctor will also look at your full health history, including past and current medical conditions, family history, previous weight loss attempts, and medications. All these factors help determine if a GLP-1 medication is right for you.

3. Are GLP-1s safe? What are the side effects?

GLP-1s have been extensively studied and are considered safe when prescribed and monitored by a healthcare provider. But, like any medication, they come with potential side effects, including:

• Nausea, vomiting, constipation and diarrhea
• Fatigue or dizziness (especially as your body adjusts)
• Muscle loss (if you’re not eating enough)

One lesser-known side effect? Forgetting to eat.

“GLP-1s slow food moving through the intestines. It tells your brain it’s not hungry,” says Sara Fausett, a registered dietitian at Intermountain Health Cedar City Hospital. “I’ve had to remind some of my clients that they still need to eat.”

4. How do you get the most out of your GLP-1 treatment?

GLP-1s can help you lose weight, but they aren’t a magic fix. To see the best results, you’ll need to combine them with healthy habits.

• Eat balanced meals – Focus on protein, fiber, and healthy fats to support muscle and metabolism.
• Move your body – Find an activity you enjoy, whether it’s walking, yoga, or strength training.
• Work with a dietitian – A nutrition expert can help make sure you’re eating enough while losing weight.

5. What happens when you stop taking GLP-1s?

There is a potential to regain the lost weight, but those chances decrease when you work with a healthcare provider to transition off the medication safely. Experts also recommend continuing to practice mindful eating and portion control as well as exercising regularly to support a healthy metabolism.

“All the clinical trials that showed these medications working also included education on eating and exercise,” explains Welch. “We see much greater success when lifestyle changes are part of the plan.”

6. Where can you get GLP-1s?

Many online services now offer quick prescriptions for GLP-1s. But going through a trusted healthcare provider is a safer option.

“Many direct-to-consumer brands don’t have full access to a patient’s medical history,” Welch explains. “That can lead to gaps in treatment, making the medication less effective or even unsafe.”

Choosing an integrated healthcare system like Intermountain gives you access to pharmacists and physicians who ensure your medication is safe and effective, and monitor your progress and adjust treatment as needed, and nutrition experts who help you make sustainable lifestyle changes.

How do I get started with Intermountain Health’s GLP-1 program?

With Intermountain Health’s online program, you can easily start your weight loss journey from home. Here’s how it works:

• Step one: Complete a health assessment form online.
• Step two: Consult with a pharmacist over the phone.
• Step three: Receive your medication at your doorstep.

The future of GLP-1s is exciting

GLP-1s are already changing lives, but weight loss is just the beginning. “New research suggests GLP-1s may also help improve cholesterol levels, reduce heart disease risk, and even support kidney and liver health,” Welch says.

If you’ve struggled with weight loss, this could be the breakthrough you’ve been waiting for.

*Program fee is $49 plus the cost of medication (approx. $350-500 monthly). For patients 18 years or older located in Utah, Idaho, Montana, Colorado and Nevada.