What is a bone marrow transplant?
Bone marrow transplantation, also known as blood and marrow transplantation, has evolved over the past 20 years into a successful therapy for a variety of malignant and non-malignant diseases that, in the past, would not have been curable. It has been proven to help with many cancer-related illnesses and some autoimmune diseases, such as leukemia, lymphoma, myeloma, and aplastic anemia.
Bone marrow transplantation involves the replacement of stem cells from bone marrow following a high dose of chemotherapy and radiation. You and your transplant physician will decide which type of transplant is the best treatment option for you. The two main types are allogeneic, a donor supplies the marrow or stem cells, and autologous, the patient's own bone marrow or stem cells are used.
CAR T-cell Therapy is FDA approved as standard of care for some forms of non-Hodgkin lymphoma and a type of leukemia. These include acute lymphoblastic leukemia (only available for patients up to
age 26), and certain types of large B-cell lymphoma.
- No history of or active CNS lymphoma or other CNS disease
- Adequate organ function
- Adequate cardiac function
- Adequate pulmonary function
- Absence of malignancy in the past 3 years other than non-melanoma skin cancer
- No history of allogenic stem cell transplant
- No history of autoimmune disease requiring systemic immunosuppression in the past 2 years
- No history of HIV or active hepatitis B or C patients