The path to understanding and overcoming advanced cancer begins with Intermountain Precision Genomics' TheraMap test, a personalized approach to cancer care.
By customizing care to patients’ DNA and matching them with targeted treatments, TheraMap can help improve results and reduce costs. This way, patients can spend less time worrying about treatment and enjoy an improved quality of life.
By streamlining the process of genomics sequencing, implementing clinical guidance, and shifting focus to targeted therapies, our advanced-stage cancer patients enjoy a better quality of life.
TheraMap simpliﬁes patient care for oncologists by providing straightforward interpretations, prioritization of therapies, and the next steps speciﬁc to each patient’s genomic results.
TheraMap Testing Options
- TheraMap Solid Tumor Comprehensive Panel
The TheraMap Solid Tumor Panel is a hybrid capture DNA- and RNA-based test that detects SNV, INDELs, Copy Number Variants (CNV), and fusions in solid tumors. TheraMap is validated for all solid tumor types and includes sequencing over 500 genes identified as relevant to cancer treatment, relevant gene fusion events, including NTRK fusions, as well as the important microsatellite instability (MSI) and tumor mutational burden (TMB) biomarkers.
- TheraMap Solid Tumor Focus Panel
When there is not enough tissue to run the comprehensive TheraMap test, the Precision Genomics lab offers a smaller panel designed to perform genomic testing on difficult-to-sample cancers. TheraMap Focused Lung employs cutting-edge science to detect 35 key genes by DNA sequencing, 23 genes by RNA sequencing, as well as NTRK fusions.
TheraMap analyzes the DNA sequences of over 500 genes, and the RNA sequences of 54 genes, detecting SNVs, INDELS, Copy Number Variants (CNV), gene fusions, and breakpoints in solid tumors. In contrast to amplicon or other targeted methods, TheraMap has a hybrid capture technology that is one of the most sensitive methodologies for detecting gene fusion events from known and novel partners. TheraMap is one of the first available clinical tests that can detect any oncogenic fusions event in NTRK1, NTRK2, and NTRK3, a critical biomarker with the recent approval of Vitrakvi (larotrectinib).
If the sample size is insufficient, the Precision Genomics lab will default to the Solid Tumor Focus Panel to utilize the sample available.
Download the gene lists here:
- The ordering oncologist first completes the test requisition, which alerts Intermountain Precision Genomics to begin the sample acquisition process.
- Once the specimen is received, the Intermountain Precision Genomics CAP and CLIA certified laboratory utilizes state-of-the-art next-generation sequencing, additional molecular methods, and proprietary data analytics, to identify all clinically relevant cancer mutations.
- The Molecular Tumor Board, a group of clinical experts and precision medicine key opinion leaders then reviews TheraMap Solid Tumor results and provides recommendations for specific therapies and treatments.
- A report is sent to the ordering provider with treatment information on variants that are clinically actionable and a list of available clinical trials.
Fill out this form to have a member of the Intermountain Precision Genomics team get your office set up to begin ordering TheraMap or download the order form here and fax the completed form to (435) 251-5781.
Please reference this document for specimen and shipping requirements.
Your TheraMap test results will come as formatted in this sample report.
While some insurance companies cover genetic testing, please work with the patient’s insurance company for any pre-authorization requirements prior to ordering. If you have any questions, or would like assistance, please call our customer service representatives at (435) 251-5780.
Dr. Derrick Haslem, MD, Associate Medical Director of Oncology, et al, composed a study on precision cancer medicine in patients with advanced-stage cancer, finding those who received precision medicine treatment had improved clinical outcomes without increasing healthcare costs. Download and read the publication: Haslem et al | Journal of Oncology Practice.